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The trip to Mars destroys the human body. The solution? Put it on pause. 🚀💤 We investigate the science of Synthetic Torpor, a state of suspended animation that could reduce a mission's mass by 68%. We break down the "Sentinel Protocol," where astronauts rotate through drug-induced hibernation to survive the 400-day journey.
1. The Bone Crisis: Gravity is essential. We analyze the medical data. In microgravity, astronauts lose 1-2% of bone density per month, risking catastrophic fractures upon landing. We explain why current exercise machines fail to stop this and why putting the metabolism on "ice" might the only way to halt the body's self-destruction.
2. The "Black Bear" Model: It’s not freezing; it’s cooling. We expose the biology. Unlike sci-fi cryosleep, scientists are mimicking the Black Bear, which cools only slightly (to ~30°C) but cuts metabolism by 75%. We discuss the use of Total Parenteral Nutrition (TPN)—pumping liquid food directly into the veins—which eliminates the need for eating or producing waste for months.
3. The Xenon Switch: How do you keep them asleep? We explore the pharmacology. Researchers identified Xenon gas and Dexmedetomidine as the perfect agents to suppress shivering and protect the brain. We discuss the added benefit: hypoxic (low oxygen) cells in torpor are naturally resistant to deadly cosmic radiation.
The full list of sources used to create this episode can be found on our Patreon under https://www.patreon.com/c/Morgrain
By MorgrainThe trip to Mars destroys the human body. The solution? Put it on pause. 🚀💤 We investigate the science of Synthetic Torpor, a state of suspended animation that could reduce a mission's mass by 68%. We break down the "Sentinel Protocol," where astronauts rotate through drug-induced hibernation to survive the 400-day journey.
1. The Bone Crisis: Gravity is essential. We analyze the medical data. In microgravity, astronauts lose 1-2% of bone density per month, risking catastrophic fractures upon landing. We explain why current exercise machines fail to stop this and why putting the metabolism on "ice" might the only way to halt the body's self-destruction.
2. The "Black Bear" Model: It’s not freezing; it’s cooling. We expose the biology. Unlike sci-fi cryosleep, scientists are mimicking the Black Bear, which cools only slightly (to ~30°C) but cuts metabolism by 75%. We discuss the use of Total Parenteral Nutrition (TPN)—pumping liquid food directly into the veins—which eliminates the need for eating or producing waste for months.
3. The Xenon Switch: How do you keep them asleep? We explore the pharmacology. Researchers identified Xenon gas and Dexmedetomidine as the perfect agents to suppress shivering and protect the brain. We discuss the added benefit: hypoxic (low oxygen) cells in torpor are naturally resistant to deadly cosmic radiation.
The full list of sources used to create this episode can be found on our Patreon under https://www.patreon.com/c/Morgrain