This episode of TTS Podcast explores “Smarter Organ Allocation: AI, Policy, and KDPI Optimization”, focusing on how recent U.S. policy reforms like continuous distribution, kidney expedited placement protocols, and updated scoring systems (KDPI, EPTS, MELD 3.0) are reshaping transplant equity and efficiency. It examines cutting-edge AI applications in donor-recipient matching, survival prediction, and real-time decision support, alongside integration with electronic health records and predictive analytics tools. By merging data-driven models with evolving allocation frameworks, these innovations aim to maximize graft utility, reduce organ discard, and ensure fairer access across all organ types, marking a transformative era in transplantation.