The greater context of chapter 40 is a call to behold the glory of God (vs. 9) and know (vs. 21, 28) that God stands alone in His glory and power, and in Him alone is hope. Here is the whole sermon in one sentence: If you turn your attention to God, the problems of this world become small, but if you give your attention only to the problems of this world, they will overwhelm you. Through the prophet Isaiah, God is calling His people to look and see and behold His glory.