Prof Sydes is Professor of Clinical Trials & Methodology at the MRC CTU at UCL. He co-leads the Trial Conduct Methodology programme whilst also under secondment to co-lead the Data-Enabled Trials theme for the BHF Data Science Centre, led by Health Data Research UK.  There is so much insight in this episode for trainees thinking about (or doing) real-world data science research. From the early retrospective audits using EHR data to handling national-level big data, this analytical approach to big questions is growing and growing. It's an important one to understand- practically + the implications and so we are privileged to have had Prof Sydes talk through the key issues here today.