While there are now many effective drug treatments for PAH and PH, new molecular pathways of disease offer horizons for novel therapeutic developments that may, alone or in combination with existing, approved medications, alter the process of PH as a disease. This program examines some of the bright lights on the horizon of PH treatment and emerging drug delivery approaches to getting PH medications to their intended site of action. The emergence of these new agents could radically alter the way we think about combination therapy for PAH and other forms of PH.