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Splice the Signal
This release contains only the music track from Base by Base Episode 317.
Song title: Splice the Signal
Original Base by Base episode: 317: COPD sQTL colocalization in lung and blood identifies FBXO38 and BTC splicing mechanisms
Original episode link: https://basebybase.com/episodes/copd-sqtl-fbxo38-btc
Article metadata:
Article title: Overlap between COPD genetic association results and transcriptional quantitative trait loci
Journal: Human Genetics and Genomics Advances
DOI: 10.1016/j.xhgg.2025.100493
Reference: Saferali A., Kim W., Chase R.P., NHLBI TransOmics in Precision Medicine (TOPMed), Vollmers C., Silverman E.K., Cho M.H., Castaldi P.J., Hersh C.P. Overlap between COPD genetic association results and transcriptional quantitative trait loci. Human Genetics and Genomics Advances. 2026 Jan 15;7:100493. https://doi.org/10.1016/j.xhgg.2025.100493.
Lyrics:
Verse 1
Under cold white light and a humming screen,
We chase a risk that hides in-between.
Not in the obvious cut or seam—
But upstream shadows in the gene.
Pre-Chorus
Windows line up like constellations in the dark,
Bayes in the background, waiting for the spark.
If the maps agree, we’re finally close—
To the mechanism nobody chose.
Chorus
Splice the signal, let it show,
In the lung where the quiet changes grow.
One wrong turn, one hidden frame,
And the cell forgets to say your name.
Splice the signal—clear and bright,
Turn the noise into a line of light.
Verse 2
A cryptic exon slips inside,
Premature stop—then it can’t survive.
The message drops, decay rolls in,
And expression falls like a swallowed hymn.
Another exon shifts the shape,
Isoforms trade places, escape and take.
Bridge
Long-read truth in a single thread,
Sashimi arcs where the splice was led.
Thirty-three doors in the same old wall,
Thirty-eight times the echoes call.
We don’t just count—we understand:
Risk has hands, and hands can be planned.
Final Chorus
Splice the signal, let it show,
From blood to lung where the answers glow.
Not fate, not fog—just moving parts,
A map of endings, a start of starts.
Splice the signal—hold on tight,
Name the isoform, aim the fight,
And when the pattern locks in place,
We give the future breathing space.
View all episodes
By Gustavo Barcelos BarraThis release contains only the music track from Base by Base Episode 317.
Song title: Splice the Signal
Original Base by Base episode: 317: COPD sQTL colocalization in lung and blood identifies FBXO38 and BTC splicing mechanisms
Original episode link: https://basebybase.com/episodes/copd-sqtl-fbxo38-btc
Article metadata:
Article title: Overlap between COPD genetic association results and transcriptional quantitative trait loci
Journal: Human Genetics and Genomics Advances
DOI: 10.1016/j.xhgg.2025.100493
Reference: Saferali A., Kim W., Chase R.P., NHLBI TransOmics in Precision Medicine (TOPMed), Vollmers C., Silverman E.K., Cho M.H., Castaldi P.J., Hersh C.P. Overlap between COPD genetic association results and transcriptional quantitative trait loci. Human Genetics and Genomics Advances. 2026 Jan 15;7:100493. https://doi.org/10.1016/j.xhgg.2025.100493.
Lyrics:
Verse 1
Under cold white light and a humming screen,
We chase a risk that hides in-between.
Not in the obvious cut or seam—
But upstream shadows in the gene.
Pre-Chorus
Windows line up like constellations in the dark,
Bayes in the background, waiting for the spark.
If the maps agree, we’re finally close—
To the mechanism nobody chose.
Chorus
Splice the signal, let it show,
In the lung where the quiet changes grow.
One wrong turn, one hidden frame,
And the cell forgets to say your name.
Splice the signal—clear and bright,
Turn the noise into a line of light.
Verse 2
A cryptic exon slips inside,
Premature stop—then it can’t survive.
The message drops, decay rolls in,
And expression falls like a swallowed hymn.
Another exon shifts the shape,
Isoforms trade places, escape and take.
Bridge
Long-read truth in a single thread,
Sashimi arcs where the splice was led.
Thirty-three doors in the same old wall,
Thirty-eight times the echoes call.
We don’t just count—we understand:
Risk has hands, and hands can be planned.
Final Chorus
Splice the signal, let it show,
From blood to lung where the answers glow.
Not fate, not fog—just moving parts,
A map of endings, a start of starts.
Splice the signal—hold on tight,
Name the isoform, aim the fight,
And when the pattern locks in place,
We give the future breathing space.