She was married to John Lennon of the Beatles from 1969 until his murder in 1980.

Their affair began in May 1968. While Lennon's wife Cynthia was in Greece with Magic Alex Mardas, he and Ono recorded an album of experimental sounds at Weybridge, Lennon's Weybridge home. After its completion they made love for the first time. When Cynthia returned to England it was clear that her marriage was over.

On 8 December 1980 Lennon was murdered outside the Dakota while returning with Ono from a recording session. Following his death, Ono became a recluse for many months.

Yoko Ono continues to be active in the fields of art, music and peace campaigning.