The episode with Professor and Middle East expert Stephen Zunes began with Professor Michael Krasny asking about the victory of HTS over Assad in Syria and the poison weapons that remain there, as well as what to expect of the new government and its effect on ISIS, the Kurds, and migration.

Krasny spoke of the profound enmity and divisions, and he and Zunes discussed prospects for democracy and the ongoing conflict between Israel and the Palestinians. Talk of Iran's role, the Houthis and Yemen, secularism, and the Sunni/Shia divide followed, as did discussion of Saudi Arabia rebranding itself, rising anti-Semitism, and "intifada" and "jihad" as triggering words. A listener posed questions about Egypt refusing to open its borders to Palestinians.

Krasny then brought up the question of possible paths to peace and how best to determine bad actors from good ones in the region, as well as the likely effects of ongoing turmoil there and the effect of change in Syria on Russia's Putin and the ongoing war in Ukraine. The episode concluded with a listener's question about if and when Jewish Americans will be permitted to visit Syria.