Vidcast:  https://youtu.be/HJqsTYYKtI0

 

Breast cancer cells break off from a primary tumor, penetrate  blood vessels to reach the bloodstream highway that takes them to distant organs, and thereby metastasize.  Israeli researchers have already identified the cellular “drills” that facilitate this penetration and named them invadopodia.  Now they announce discovery of a peptide protein that blocks invadopodia formation by mimicking the natural protein Pyk2 and blocks its interaction with the coractin protein necessary for invadopodia formation.  Now they work on perfecting this coractin-blocking protein into a clinical drug.

 

https://www.nature.com/articles/s41388-022-02481-w

 

#breastcancer #metastasis #invadopodia #pyk2 #coractin