Medizin - Open Access LMU - Teil 12/22

Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapine


Listen Later

The aim of this investigation was to compare the degree of striatal dopamine-(D2) receptor blockade by two atypical antipsychotic drugs, risperidone and olanzapine. The percentage of D2 receptor occupancy during treatment was calculated by comparing the results of 123I-iodobenzamide SPECT with those from healthy control subjects. Twenty inpatients suffering from schizophrenia or schizoaffective psychosis according to DSM IV/ICD-10 criteria were treated with clinically recommended doses of risperidone and compared with 13 inpatients treated with up to 20 mg olanzapine. Neuroleptic dose and D2 receptor blockade correlated strongly for both risperidone (Pearson r = –0.86, p = 0.0001) and olanzapine (Pearson r = –0.77, p = 0.002). There was no significant difference between the D2 receptor occupancy of the two substances when given in the clinically recommended dose range (unpaired t-test, t= –0.112, p=0.911).
...more
View all episodesView all episodes
Download on the App Store

Medizin - Open Access LMU - Teil 12/22By Ludwig-Maximilians-Universität München


More shows like Medizin - Open Access LMU - Teil 12/22

View all
In search of dark matter by Prof. Dr. Andreas Burkert

In search of dark matter

0 Listeners

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 03/06 by Ludwig-Maximilians-Universität München

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 03/06

0 Listeners

Hegel lectures by Robert Brandom, LMU Munich by Robert Brandom, Axel Hutter

Hegel lectures by Robert Brandom, LMU Munich

6 Listeners

LMU Rechtsphilosophie by Prof. Dr. jur. Dr. jur. h.c. mult. Bernd Schünemann

LMU Rechtsphilosophie

0 Listeners

MCMP – Philosophy of Science by MCMP Team

MCMP – Philosophy of Science

1 Listeners

Epistemology and Philosophy of Science: Prof. Dr. Stephan Hartmann – SD by Ludwig-Maximilians-Universität München

Epistemology and Philosophy of Science: Prof. Dr. Stephan Hartmann – SD

2 Listeners

ISCB34 - 34th Annual Conference of the International Society for Clinical Biostatistics - Munich, 25-29 August 2013 by Prof. Dr. rer. nat. Ulrich Mansmann

ISCB34 - 34th Annual Conference of the International Society for Clinical Biostatistics - Munich, 25-29 August 2013

0 Listeners

MCMP – Philosophy of Physics by MCMP Team

MCMP – Philosophy of Physics

3 Listeners

Strings Conference 2012 (LMU) by Prof. Dr. Dieter Lüst et al.

Strings Conference 2012 (LMU)

0 Listeners

Women Thinkers in Antiquity and the Middle Ages - SD by Peter Adamson

Women Thinkers in Antiquity and the Middle Ages - SD

0 Listeners