The sermon centers on the prophetic symbolism of Revelation 11 and Daniel 12, interpreting the temple and its courts as representations of the true and false church, with the inner sanctuary symbolizing faithful believers and the outer court representing the corrupted Church of Rome. It argues that the 'daily sacrifice' taken away and the 'abomination that maketh desolate' refer not to historical events like Antiochus or the Romans, but to the papal antichrist's perversion of Christ's once-offered sacrifice through the doctrine of transubstantiation and the idolatrous worship of the Eucharist, which the speaker views as a greater abomination due to its professed Christian identity. The passage emphasizes that this spiritual desolation leads to persecution of faithful witnesses, illustrated by the martyrdom of English Reformers under Mary I, and calls believers to courage rooted not in the absence of fear but in reliance on God's grace, affirming that true faith endures even under threat of death.