Superior vena cava (SVC) syndrome is characterized by facial plethora, upper body venous engorgement, chest pain, soft tissue swelling, dyspnea, and even neurologic changes. Anything that impairs SVC drainage by intrinsic obstruction (thrombosis, anatomic narrowing) or extrinsic compression (mediastinal masses, non-small cell lung cancer, non-Hodgkin’s lymphoma, etc.) can result in this syndrome. Remember, venous structures …