The Great Molasses Flood, sometimes referred to locally as the Boston Molassacre, occurred on January 15, 1919, in the North End neighborhood of Boston, Massachusetts. This event killed 21 people and created a 40-foot wave of molasses which buckled the elevated railroad tracks, crushed buildings and inundated the neighborhood.

In 2008 the Georgia sugar refinery explosion was an industrial disaster that occurred on February 7, 2008, in Port Wentworth, Georgia. Fourteen people were killed and forty injured when a dust explosion occurred at a sugar refinery owned by Imperial Sugar.