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Systemic Lupus Erythematosus: Condition Workup
Systemic Lupus Erythematosus: Pathophysiology, Clinical Features, Investigation and Managment.
In this episode, we explore the pathophysiology of Systemic Lupus Erythematosus (SLE), a complex autoimmune disease. Discover the genetic and environmental factors, such as UV light and viral infections, that contribute to SLE onset. We cover the role of autoantibodies, immune complexes, and the genetic markers HLA-DR2 and HLA-DR3. Learn about the most important symptoms using bespoke mneumonics, and understand the role of ANA, anti-dsDNA, and complement proteins in diagnosis. Finally, we discuss treatments, from hydroxychloroquine and NSAIDs to corticosteroids and immunosuppressive therapies, along with the importance of lifestyle modifications for effective SLE management.
Memory pegs used:
Risk factors BAmeS FFAME, 3 bait drs
Clinical Features: OPRAS DMV LAPS
Management: 1st line - SHIELD, 2nd line - CAMP
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By Hayder AnchorSystemic Lupus Erythematosus: Pathophysiology, Clinical Features, Investigation and Managment.
In this episode, we explore the pathophysiology of Systemic Lupus Erythematosus (SLE), a complex autoimmune disease. Discover the genetic and environmental factors, such as UV light and viral infections, that contribute to SLE onset. We cover the role of autoantibodies, immune complexes, and the genetic markers HLA-DR2 and HLA-DR3. Learn about the most important symptoms using bespoke mneumonics, and understand the role of ANA, anti-dsDNA, and complement proteins in diagnosis. Finally, we discuss treatments, from hydroxychloroquine and NSAIDs to corticosteroids and immunosuppressive therapies, along with the importance of lifestyle modifications for effective SLE management.
Memory pegs used:
Risk factors BAmeS FFAME, 3 bait drs
Clinical Features: OPRAS DMV LAPS
Management: 1st line - SHIELD, 2nd line - CAMP