In this Healthed lecture, Clinical A/Prof David Horgan, Honorary Psychiatrist, Royal Melbourne Hospital; Founder, Australian Suicide Prevention Foundation; Clinical Associate Professor, Department of Psychiatry, University of Melbourne, describes the various features of depressive illness and how to select the therapeutic agents based on the likely clinical efficacy for a given individual. The side effect profile must also be considered. Both should be discussed with patient. This has been emphasised in the new mood disorders guidelines.

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