The use of tamsulosin for renal colic makes physiological sense, but the majority of studies supporting it have been small, prone to bias or methodologically flawed. In the last 9 years, three higher-quality RCTs have been published, finding little to support tamsulosin use. The STONE study is the most recent trial to wade into the debate and is the largest RCT on the subject to date.

 

JAMA Internal Medicine, August 2018