In an engaging conversation with Dr. Titas Sengupta, we delve into the intricate processes guiding the placement of neurites in specific neural layers during brain development. Utilizing groundbreaking imaging techniques and advanced quantitative models, Dr. Sengupta unveils his findings on the embryonic development of the C. elegans brain neuropil. At the core of this exploration lies the profound role of differential adhesion, orchestrated by the interaction between IgCAM SYG-1 and its ligand partner, SYG-2. Rather than the anticipated outgrowth method, neurites are found to employ a unique "retrograde zippering" mechanism, which governs their precise placement. Through this study, Dr. Sengupta bridges the realm of biophysics with neural development, offering fresh perspectives on how synaptic specificity is achieved in the developing brain.

Keywords:

Neurites

Synaptic specificity

C. elegans brain neuropil

Differential adhesion

IgCAM SYG-1

SYG-2

Retrograde zippering

Neural development

Circuit formation

Biophysical principles

Neurite placement.

https://doi.org/10.7554/eLife.71171.sa0