Originally Aired: October 2, 1960

Gunsmoke #443, "The Big Itch," brings Marshal Matt Dillon into a troubling mystery when Samantha Church arrives in his office seeking help. Her husband George left their ranch two days earlier to pay off their bank note with money from their first big cattle sale, but he never made it to the bank and hasn't been seen since. The only lead is that rancher Hobie Price was spotted riding off with George that Monday morning, and Hobie was later seen at the Long Branch that night, spending money freely and buying drinks for everyone. When Matt questions Kitty about Hobie's behavior, she confirms he was drinking heavily and throwing cash around like there was no tomorrow.

Matt and Chester search the countryside between the Church ranch and Dodge City, looking for any sign of what might have happened to George. They question Ben Stanley, the young man the Churches raised after his parents were killed in a raid, but he has no helpful information beyond confirming George's eagerness to pay off the debt. As the investigation stalls with no trace of either George or Hobie Price, Chester begins developing a mysterious rash that demands Doc's attention.