The Big Question is a one-hour TV program in South Africa, featuring a heated debate between Dr. David Rasnick and Professor Sam Mhlongo against two spokesmen for the AIDS Establishment. The topic is the efficacy of anti-retroviral drugs. Near the beginning, reporters are interviewing people in South Africa on both sides of the issue, and perhaps the most striking thing is to notice how sick those who are taking the ARVs look (from lipodystrophy, one of the side-effects of the drugs), and how well and healthy the people look who are not taking the drugs. "It never made sense that when people are sick to treat them with toxic chemicals."