On this episode we feature the CEO of Resolution Therapeutics, Amir Hefni. Throughout his career, Amir has held roles with global powerhouses such as BMS, Ipsen, & Novartis, before transitioning to small biotech with Resolution in 2023.

Resolution's pipeline of regenerative macrophage therapies originates from research out of Edinburgh University. With potential across inflammatory & fibrotic diseases, the team are currently focused on patients with end-stage liver cirrhosis who otherwise only have transplantation as a treatment option.

Tune in to hear more about Resolution's ongoing ph1/2 trials & what to look out for from them in 2026. We also discussed Amir's findings during the transition from big pharma to small biotech, plus the pro's & con's of building in biotech in The UK.

Today’s guest is Justin To, a leader at the forefront of biotech innovation and gene therapy. Justin currently serves as CEO of QED Therapeutics, a BridgeBio company, where he helps guide the development of treatments for rare genetic diseases.

With a background that spans strategy consulting at McKinsey, healthcare technology at Flatiron Health, and multiple leadership roles at BridgeBio, Justin brings a unique blend of scientific rigor, operational leadership, and business insight. He’s worked across the full lifecycle of drug development—from early strategy to commercialization—always with a focus on making a real impact for patients with unmet medical needs.

Justin is also a Harvard-trained chemist, graduating magna cum laude with highest honors, and he’s passionate about translating complex science into therapies that can truly change lives.

We recently sat down with Miquel Vila-Perello, CEO of SpliceBio, at Jefferies - during which the team picked up the Series B Raise of the Year at the 2025 ELAs for their $135million round earlier this year.

SpliceBio are a Barcelona-based gene therapy company using a proprietary Protein Splicing platform to address diseases caused by large genes that traditional AAV vectors can’t deliver. Their lead program, SB-007 for Stargardt disease, is currently being investigated in their Phase 1/2 ASTRA study, marking a key clinical milestone in a condition with no approved treatments.

It was great to sit down with Miquel and hear about his journey in biotech & the origins of SpliceBio. He also shared some advice for other scientific co-founders stepping into the CEO-hotseat & his take on why Barcelona is well positioned to be the next EU biotech hot-spot.

We were delighted to be joined by Jason Cole, a seasonedbiotechnology executive and the CEO of Zag Bio, a Cambridge-based biotech company taking a novel approach to autoimmune disease, onto The BioHub!

Jason brings more than two decades of leadership experience across the biotech industry, spanning company formation, drug development, corporate strategy, and commercialization. Before joining Zag Bio, he heldsenior executive roles at several innovative life-science companies, including bluebird bio, where he served in multiple leadership positions across strategy, operations, finance, and legal affairs. He has also led and advised emerging biotech companies as both a CEO and board member.

At Zag Bio, Jason is leading a bold effort to rethinkhow autoimmune diseases are treated. Their work aims to address the root cause of autoimmunity, with the potential for more durable and transformative therapies.

We’re excited to talk with Jason today about his careerjourney, the science behind Zag Bio, and what it takes to build the next generation of biotech innovation.

Today on The BioHub, I’m joined by Brendan Teehan, Chief Commercial Officer at Pacira BioSciences.

Brendan has spent three decades building and leading commercial teams across biopharma, from Johnson & Johnson to Amgen, Tesaro, and Acadia.

Now at Pacira, he’s driving the company’s mission to transform pain management through innovative non-opioid therapies.

In this conversation, we get into what inspired him to join Pacira, how the company has evolved, and how they’ve aligned the entire organization around a clear and bold mission. We also dive into leadership, culture, and the future of pain management.

Let’s get into it.

We recently spoke to Lance Baldo, CEO of Beacon Therapeutics, during the Jefferies Healthcare Conference. 

Beacon's Vista ph3 trial for laru-zova, their AAV Gene Therapy for X-Linked Retinitis Pigmentosa, has completed enrolment with topline expected in mid-2026.

Listen in to hear about Lance's career, from roles with Roche in both Switzerland & New Zealand to a return to the US with Genentech's ophthalmology division, and how he's drawn on those experiences in his role as CEO of Beacon.

We also cover Lance's experience as a first-time CEO, and his advice for other executives making that transition, on topics as broad as fundraising, regulatory discussions, and team building. 

And of course, we cover the story behind Beacon & their mission to deliver a step-change for XLRP patients globally. 

Welcome to The BioHub Podcast.

I’m joined by Luba Greenwood, CEO of Gallop.

Luba’s one of the most respected voices in biotech — a three-time CEO, founder of Binney Street Capital at Dana-Farber, and a driving force behind Biotech Hangout.

We talk about Gallop’s mission, what it takes to build strong culture in tough markets, and the personal motivation behind her work after losing her mum to cancer.

It’s an inspiring and powerful conversation — let’s get intoit.

Today we’re joined by a leader at the forefront of next-generation immunotherapy — Dr. Christian Leisner. Christian is the CEO and co-founder of CDR-Life, a biotechnology company pioneering a new class of highly targeted T-cell engaging therapies designed to tackle some of the most difficult-to-treat cancers.

With a PhD in Biochemistry from ETH Zurich and a Master’s in Molecular Biology and Chemistry from Roskilde University in Denmark, Christian has built a career that bridges deep scientific expertise with strategic leadership. Before launching CDR-Life, he held key roles at Novartis, Alcon, and the biotech success story ESBATech, contributing to global development programs across oncology, ophthalmology, autoimmunity, and cardiovascular disease.

Today, Christian leads CDR-Life’s mission to unlock the potential of MHC-targeted immunotherapies — developing treatments designed to precisely attack tumor cells by recognizing intracellular antigens, long thought to be ‘undruggable.’ Under his leadership, the company is shaping what could become a transformational approach in the fight against cancer.

We’re thrilled to have him with us today to explore the science, the strategy, and the future of immunotherapy

We were delighted to welcome Dr. Christina Coughlin, CEO of Avacta Therapeutics, onto The BioHub! Avacta are a clinical-stage biotech pioneering next-generation oncology therapies.

With a remarkable career spanning top pharmaceutical companies and cutting-edge biotech — from Immunocore and Rubius Therapeutics to Tmunity and CytoImmune — Christina brings a unique blend of medical expertise, scientific insight, and leadership acumen. At Avacta, she is driving the development of groundbreaking therapeutics, leveraging proprietary platforms like pre|CISION™, with the goal of bringing life-changing treatments from lab to clinic.

In this episode, we’ll explore her journey from clinician-scientist to biotech executive, the vision and science behind Avacta, and the challenges and opportunities in developing innovative cancer therapies in today’s evolving regulatory and commercial landscape.

Welcome to another Episode of The Biohub

Today, I’m joined by Jill Howe, Chief Financial Officer at Lineage Cell Therapeutics, a company developing groundbreaking allogeneic cell therapies for conditions like dry AMD, spinal cord injury, and hearing loss.

Jill’s career spans more than 20 years across some of biotech’s most successful companies, helping take both Receptos and Gossamer Bio public before stepping into her current role at Lineage.

We talk about what inspired her to join the company, how shehelps shape and protect Lineage’s culture, what excites her most about their pipeline, and her perspective on leadership and women in biotech.

Let’s get into it.