This episode provides an in-depth exploration of the origins and early outbreaks of the Bubonic Plague. It begins by defining the disease and its symptoms, then delves into historical references from ancient civilizations. The episode focuses significantly on the Plague of Justinian in the 6th century CE, detailing its spread, impact, and consequences. It also explains the nature of the Yersinia pestis bacterium, its transmission via fleas and rodents, and its evolution. The article discusses the plague's effects on societies, economies, and cultures, and highlights how studying these early outbreaks provides valuable insights for understanding and managing modern pandemics. Throughout, it emphasizes the interconnectedness of human health, history, and the environment.