Today's guests are Alex Ksendzovsky and Jon Pomeraniec, co-founders of The Biological Computing Company (TBC).

Check out the demo here! www.tbc.co/demo

Alex and John are both neurosurgeon-neuroscientists who met about fifteen years ago and have done nearly everything together since. Alex is the godfather to John's two kids and signed his wedding documents, in Russian. The idea for TBC traces back to Alex's time as a philosophy student, when he pitched his neuroscience professor on encoding the S&P 500 into a dish of living neurons to predict the stock market. The professor said no. Years later, once they were both practicing neurosurgeons, Alex and John ran the experiment anyway. The market prediction didn't pan out, but it proved something bigger: that real-world data could be encoded into living neurons, processed, and decoded back out again. That became the premise for TBC: growing neurons on dishes wired to thousands of electrodes and deriving learning principles from them to make today's AI models faster, cheaper, and more efficient. The company came out of stealth this year having raised $50M at seed, grown from 5 people to 25, and signed its first paying customers for a neuron-derived video generation model. We're thrilled to have Alex and John on the podcast for a conversation about building the first company with real commercial access to biological compute, why the brain is still the best computer ever built, and what it will take to eventually put neurons directly in the compute loop.

Alex: https://www.linkedin.com/in/alexander-ksendzovsky-31732711/

Jon: https://www.linkedin.com/in/jonathan-pomeraniec-785a294/

The Compute 100 is led by Brian Schechter and Gaby Lorenzi, compute-focused investors at Primary. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary's compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Primary: https://www.primary.vc/

Follow us on X (https://x.com/thecompute100) and check out our daily newsletter (https://newsletter.thecompute100.com/).

This podcast is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any security. Nothing discussed in this podcast constitutes investment, legal, tax, or accounting advice, or a recommendation to make any investment. Any views expressed are as of the date of recording, are subject to change, and may include forward-looking statements that involve risks and uncertainties.

Today's guest is Shahin Farshchi, General Partner at Lux Capital.

Shahin's path into venture started with a failed startup. After a PhD at UCLA designing low-noise amplifiers to capture brain signals, he bootstrapped a wireless biosignal monitoring company and learned the hard way that hospitals wanting a product and hospitals paying for one are very different things. A mentor told him he should raise venture money next time – his response: "What's venture capital?" With no network to speak of, he cold-emailed a list of VC firms offering to scout semiconductor deals. Lux Capital, the first hit on a Google search for "nanotechnology venture capital," wrote back the same day, and he joined full-time in 2006. Nearly 20 years later, he's one of the firm's most active investors in deep tech, backing companies like Majestic Labs, Cognichip, and Unconventional AI. Lux just closed Fund IX at $1.5B, its largest ever, bringing total AUM to roughly $7B. We're thrilled to have Shahin on the podcast for a conversation about the semiconductor cycle, the case for younger founders in chips, and the shrinking universe of venture-scale outcomes.

Shahin: ⁠https://www.linkedin.com/in/shahinf⁠ Lux Capital: ⁠https://www.luxcapital.com/⁠

The Compute 100 is led by Brian Schechter and Gaby Lorenzi, compute-focused investors at Primary. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary's compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Primary: ⁠https://www.primary.vc/⁠

Follow us on X (⁠https://x.com/thecompute100⁠) and check out our daily newsletter (⁠https://newsletter.thecompute100.com/⁠).

Today's guest is Chase Lochmiller, co-founder and CEO of Crusoe.

While climbing mountains with his best friend turned co-founder, Chase first learned about gas flares — spots around the world where energy was virtually free. In 2018, the vision was clear: co-locate small data centers next to these flares, mine bitcoin, and scale. But while Crusoe grew its mining business, Chase's core long-term motivation was a side project — using low-cost, clean energy to power compute for AI. Fast forward to 2026: Crusoe is worth over $10B, has sold its bitcoin business, and is building one of the largest data centers in the country in Abilene, TX as part of OpenAI's Stargate project. With over several gigawatts of capacity under management and a newly launched managed inference platform, Crusoe is one of today's most formidable vertically integrated infrastructure companies. Chase sits at the intersection of the two most important markets of our time — energy and compute — and was spectacularly early to the insight that they're intrinsically linked. We loved this conversation with Chase, and hope you do too.

Chase: https://www.linkedin.com/in/chase-lochmiller-604483341/

The Compute 100 is led by Brian Schechter and Gaby Lorenzi, compute-focused investors at Primary. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary's compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Primary: https://www.primary.vc/

Follow us on X and check out our daily newsletter.

This podcast is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any security. Nothing discussed in this podcast constitutes investment, legal, tax, or accounting advice, or a recommendation to make any investment. Any views expressed are as of the date of recording, are subject to change, and may include forward-looking statements that involve risks and uncertainties.

Today's guest is Jeff Tatarchuk, co-founder and Chief Growth Officer of TensorWave.

Jeff is a serial entrepreneur who has spent his career building in the cloud and compute space. Before TensorWave, he co-founded VMAccel, an early FPGA cloud and edge provider, alongside his eventual TensorWave co-founder Darrick Horton. In 2023, Jeff found himself in a convo with someone looking for access to GPUs, to which Jeff posed a simple question – “how about AMD?”. The answer – an immediate “I will take anything!” – resulted in what has become Tensorwave. The company was built on a contrarian bet: that the AI world needed a serious alternative to Nvidia. TensorWave runs exclusively on AMD's hardware and ROCm software stack, and that wager is paying off. The company now operates one of the largest AMD-based AI training clusters in North America and recently raised a $350M Series B at a $1.55B valuation, co-led by Magnetar and AMD Ventures, bringing its total funding to roughly $493M. We're thrilled to have Jeff on the podcast for a conversation about building an AMD-native neocloud, the case for an open AI compute ecosystem, and the path to scaling the world beyond NVIDIA. 

Jeff: https://www.linkedin.com/in/jtatarchuk

The Compute 100 is led by Brian Schechter and Gaby Lorenzi, compute-focused investors at Primary. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary's compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Primary: https://www.primary.vc/

Follow us on X and check out our daily newsletter.

This podcast is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any security. Nothing discussed in this podcast constitutes investment, legal, tax, or accounting advice, or a recommendation to make any investment. Any views expressed are as of the date of recording, are subject to change, and may include forward-looking statements that involve risks and uncertainties.

Today's guest is Jeff Wittich, CPO of Ampere.

Jeff started his career at Intel at a device engineer, which launched a 15 year run at the company, eventually leading their cloud business and custom CPU program. In 2019, Jeff joined Ampere, where he currently acts as CPO. Ampere made an early bet on power efficiency being core to the future of AI that paid off in a big way with a $6.5B acquisition by Softbank in 2025. We're thrilled to have Jeff on the podcast for a conversation about the resurgence of the CPU, the rising generation of talent in compute and much more.

The Compute 100 is led by Brian Schechter and Gaby Lorenzi, compute-focused investors at Primary. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary’s compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Follow us on X and check out our daily newsletter.

This podcast is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any security. Nothing discussed in this podcast constitutes investment, legal, tax, or accounting advice, or a recommendation to make any investment. Any views expressed are as of the date of recording, are subject to change, and may include forward-looking statements that involve risks and uncertainties.

Today's guest is Lisa Spelman.

Lisa is currently the CEO of Cornelis Networks. Lisa's career started at Intel, where she spent almost 19 years, ending her tenure as the GM of Intel's Xeon product, their enteprise CPU line. It was there that Lisa saw the pain around high performance networking on large scale clusters, inspiring the move to the operator side. In 2024, she took the helm at Cornelis Networks, a high-performance networking company spun out of Intel in 2020 built around the OmniPath fabric architecture. Cornelis is purpose-built for the most demanding HPC and AI workloads that require massive, coordinated compute across entire data centers. Cornelis has raised over $140M since its founding in 2020. We're thrilled to have Lisa on the podcast today.

The Compute 100 is led by ⁠Brian Schechter⁠ and ⁠Gaby Lorenzi⁠, compute-focused investors at Primary⁠. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary’s compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Follow us on ⁠X⁠ and check out our ⁠daily newsletter⁠.

This podcast is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any security. Nothing discussed in this podcast constitutes investment, legal, tax, or accounting advice, or a recommendation to make any investment. Any views expressed are as of the date of recording, are subject to change, and may include forward-looking statements that involve risks and uncertainties.

Today's guest is Erik Bernhardsson.

Erik is the founder and CEO of Modal, NYC-based Series C infrastructure startup, most recently valued at $4.65B, up from their Series B at $1.1B. Modal was founded in 2021, in a pre-ChatGPT world, built to ease developer friction around deploying and running ML models at scale. The early product was inspired by Erik's time at Spotify where he built their music recommender system. Since then, Modal has become a go-to solution for developers who want fast inference across LLMs and agents. Modal is growing rapidly, hitting nearly $300M in revenue, driven by demand for their sandboxes product, which let AI agents run in isolated environments. We're thrilled to have Erik on the podcast.

The Compute 100 is led by Brian Schechter and Gaby Lorenzi, compute-focused investors at Primary. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary’s compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Follow us on X and check out our daily newsletter.

This podcast is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any security. Nothing discussed in this podcast constitutes investment, legal, tax, or accounting advice, or a recommendation to make any investment. Any views expressed are as of the date of recording, are subject to change, and may include forward-looking statements that involve risks and uncertainties.

Today's guest is Justin Selig.

Back in 2018, after hearing about the company from other graduate students, Selig joined Cerebras as an early member of their technical staff. Through 4 years with the company, he built much of their core kernel infra and the Cerebras SDK. He went on to join Eclipse Ventures, one of Cerebras' earliest backers, as an investor. From Eclipse, he joined Efficient Computer, where he works as a director, across product and BD today.

Justin was early to the opportunity unfolding today in compute. He's had an incredible seat to watching this market evolve. We hope you enjoy the conversation.

The Compute 100 is led by Brian Schechter and Gaby Lorenzi, compute-focused investors at Primary. Primary is a pre-seed and seed-stage venture firm that backs founders building across markets including compute, industrials, healthcare and vertical AI. With $1.6B AUM and a 60+ person operating team, Primary delivers unparalleled support to teams across recruiting, finance, GTM, and brand. Primary’s compute portfolio includes Etched, The Biological Computing Company, Haiqu, and Atero (acquired by Crusoe).

Follow us on X and check out our daily newsletter.

This podcast is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any security. Nothing discussed in this podcast constitutes investment, legal, tax, or accounting advice, or a recommendation to make any investment. Any views expressed are as of the date of recording, are subject to change, and may include forward-looking statements that involve risks and uncertainties.