This passage refers to Babylon as the worldwide government or kingdom of the Antichrist. The whole Antigod system of idolatry that is the worship of the Antichrist.This evil system has made all nations of the world drink of the wine of the passion of her immorality.Basically a spiritual defection from the true God. This kingdom has fallen into destruction and judgment. And a look at all the earth dwellers that received the mark of the beast will also drink of the cup of God's Wrath.