In this episode, we investigate the controversial "Set Point Theory" and the "Dual Intervention Point" model to explain why significant weight loss is biologically opposed by the human body. We explore the evolutionary "Thrifty Gene" hypothesis, revealing how our ancestors' survival mechanisms against starvation have become a modern metabolic trap.We also break down the devastating findings of the "Biggest Loser" study, which showed that metabolic rates can remain suppressed for years after dieting , and discuss why medical interventions like bariatric surgery are often necessary to reset the brain's "thermostat".