Glycerol, long dismissed as a waste product of fat-burning, turns out to be a key biological switch, according to a Nature study from the Kazak lab at McGill. The team found glycerol directly activates the enzyme TNAP, flipping on the futile creatine cycle that generates body heat. The same enzyme pocket also governs bone mineralization, linking thermogenesis and skeletal biology in one mechanism.

This episode was generated by AI from the cited research paper.