Decades of research have transformed our understanding of migraine genetics, from rare monogenic types to complex polygenic forms. Mr. Ryan Quigley is joined by Dr. Lyn Griffiths to explore polygenic risk scores, emerging diagnostic tools, and the promise of personalized medicine in migraine care. Dr. Griffiths is a Distinguished Professor and the Director of the Centre for Genomics and Personalised Health at Queensland University of Technology in Brisbane, Australia.