Greg sits down with Sophia Frangou Ph.D., Professor of psychiatry at the Ichann School of Medicine at Mt. Sinai and distinguished Brains & Behavior lecturer to discuss the initial motivation to study psychosis (1:35), how the MRI has evolved in the last 25 years (5:05), the importance at looking at brain connectivity to solve clinical questions (11:05), the recent finding she has found regarding bipolar disorder and schizophrenia (15:02), experimental design with large human populations (26:02), what new studies her group is focused on (28:32), the abuse potential of MRI (30:12), women in academic psychiatry (32:54), and life in New York city outside of science (48:08)