"My name is Ava and I've never had a hangover," writes Ava Karuso. "I'm a 25 year-old Australian and I enjoy going out for drinks. However, the next day when everyone else sleeps in and licks their wounds, I get up early and get right back to my normal routine.” Drs Rutherford and Fry investigate the ancient origins of alcohol, from Sumerians drinking beer through straws, to Aristotle's teachings ‘On Intoxication’.  But what can modern science tell us about how alcohol affects our brains? What causes the morning-after hangover and do some drinks make you feel worse than others? Are there any hangover cures that have been scientifically validated? Featuring health psychologist and hangover researcher Sally Adams, chemist Andrea Sella and science writer Adam Rogers, author of 'Proof: The Science of Booze'. Presenters: Hannah Fry, Adam Rutherford
Producer: Michelle Martin First broadcast on BBC Radio 4 in 2018.

The Horrible Hangover

Science sleuths Dr Adam Rutherford and Dr Hannah Fry investigate everyday mysteries sent by listeners.

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Behind every line on a graph, there lies an extraordinary human story. Mathematician Hannah Fry is here to tell us ten of them.

Introducing… Uncharted with Hannah Fry

There is a bizarre number in maths referred to simply as ‘i’. It appears to break the rules of arithmetic - but turns out to be utterly essential for applications across engineering and physics. We’re talking about the square root of -1. WHICH MAKES NO SENSE. Professor Fry waxes lyrical about the beauty and power of this so-called ‘imaginary’ number to a sceptical Dr Rutherford. Dr Michael Brooks tells the surprising story of the duelling Italian mathematicians who gave birth to this strange idea, and shares how Silicon Valley turned it into cold hard cash. It's all about oscillations, Professor Jeff O’Connell demonstrates. And finally, Dr Eleanor Knox reveals that imaginary numbers are indispensable for the most fundamental physics of all: quantum mechanics.  Imaginary, impossible…but essential!     Contributors: Professor Jeff O’Connell, Ohlone College California, Dr Michael Brooks, Author of 'The Maths That Made Us', and Dr Eleanor Knox, Philosopher of Physics at KCL and a Senior Visiting Fellow at the University of Pittsburgh. Producer: Ilan Goodman

The Impossible Number

This episode will render you oblivious, conked out and blissfully unaware. It’s about anaesthetics: those potent potions that send you into a deep, deathly sleep. Listener Alicia wants to know how they work, so our sleuths call on the expertise of consultant anaesthetist Dr Fiona Donald. Fiona shares her experience from the clinical frontline, and explains what we do and don’t know about how these chemicals work their mind-numbing magic. 
 
We hear about ground-breaking research led by Professor Irene Tracey, which reveals how a pattern of slow brain waves can be used to determine the optimum dosage of these dangerous drugs.  And finally, Drs Rutherford and Fry wonder: what does all this tell us about normal consciousness? Professor Anil Seth shares how we can use brain tech to measure different levels of conscious awareness – from sleepy to psychedelic. Presenters: Hannah Fry and Adam Rutherford
Producer: Ilan Goodman

The Mind Numbing Medicine

‘Can we bring back extinct species?’ wonders listener Mikko Campbell.  Well, Professor Fry is pretty excited by the prospect of woolly mammoths roaming the Siberian tundra once more. And everyone is impressed with the science that might make it happen. But Dr Rutherford comes out STRONGLY against the whole thing. Can our expert guests win him over?  Dr Helen Pilcher shares the tale of Celia the lonely mountain goat, and makes the case for cloning to help protect species at risk of extinction. Professor Beth Shapiro sets out how biotech company ‘Colossal’ plans to engineer Asian elephants’ DNA to make a new group of mammoth-like creatures. And we hear how genetic technologies are being used in conservation efforts around the world.  BUT WHAT ABOUT T-REXES? Not gonna happen. Sorry. Contributors: Dr Helen Pilcher, author of ‘Bring Back the King: The New Science of De-Extinction’, Professor Beth Shapiro from the University of California Santa Cruz, Dr Ben Novak of Revive and Restore and Tullis Matson from Nature’s SAFE. Presenters: Hannah Fry and Adam Rutherford Producer: Ilan Goodman

The Resurrection Quest

The Great Pyramids of Giza are awesome feats of engineering and precision. So who built them - and how? Was it a mysteriously super-advanced civilization now oddly extinct? Was it even aliens?   Nah, course not! Rutherford and Fry investigate how these inspiring monuments were really constructed, and learn about the complex civilisation and efficient bureaucracy that made them possible.  Professor Sarah Parcak busts the myth that they were built by slaves. In fact, she reveals, it was gangs of well-paid blokes fuelled by the ancient Egyptian equivalent of burgers and beer.  And Dr Chris Naunton explains how it was not some mysterious tech, but incredible organisation and teamwork which made it possible to transport massive stone blocks over long distances several thousand years before trucks arrived.  Dr Heba Abd El Gawad points out how racism led to bizarre assumptions in the history of archaeology, and how those assumptions linger in contemporary conspiracy theories which refuse to accept that Egyptians could have built the pyramids themselves!   Presenters: Hannah Fry and Adam Rutherford 
Contributors: Professor Sarah Parcak, University of Alabama, Dr Chris Naunton, Egyptologist and broadcaster, Dr Heba Abd El Gawad, University College London
Producers: Ilan Goodman & Emily Bird

The Horrible Hangover

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