At the intersection of nanoscience and chemistry, Omar Farha, PhD, Chair of the Department of Chemistry at Northwestern University, is opening up new frontiers in climate resilience, water harvesting, catalysis and more through metal-organic frameworks (MOFs)—versatile structures he describes as smart programmable sponges. In this episode he talks about taking on the role of chair, the legacy of those who came before him at Northwestern and discusses how the IIN is uniquely positioned to continue leading the field of nanotechnology.