In the third episode of METHYLOMIC matters we delve into the intricate machine learning methodology behind the successful prediction models developed by HORAIZON’s founder and CEO, dr. Evgeni Levin. We explore essential elements of the methodology, comparing linear and non-linear models, emphasizing the significance of multivariate models, and addressing strategies for mitigating overfitting. Furthermore, we delve into the prospective clinical applications of these models and their ultimate integration into clinical practice. All this and more in the third episode of METHYLOMIC matters!