The Man with Two Brains is a 1983 American science fictioncomedy film directed by Carl Reiner and starring Steve Martin and Kathleen Turner.

Written by Martin, Reiner and George Gipe, the film is a broad comedy, with Martin starring as Dr. Michael Hfuhruhurr, a pioneering neurosurgeon with a cruel and unfaithful new wife, Dolores Benedict (Kathleen Turner).