0:00 Pretext and context MD Anderson Cancer Center

1:42 The Early Experiences That Shaped Dr Msaouel

3:39 The System of Cancer Research In the United States

5:25 FDA Drug Approvals and Special Designations For Oncology

11:09 A trade-off in our current system

12:35 Whoops 😞 I misspoke

14:35 Randomized trials are not supposed to be representative of a population

18:10 Inference for the treatment of Katie Coleman (metastatic oncocytoma)

25:12 It is much more valuable to refute hypotheses than to confirm them

28:05 All Models Are Wrong, But Some Are Useful

30:05 Recasting the Bias-Variance Trade-off as the Patient Relevance-Robustness Trade-off

33:38 High Relevance, Low Robustness: Subjective Bayes

34:46 High Robustness, Low Relevance: Pure Randomization

41:47 Signal To Noise Ratio

45:49 The Big Data Paradox

53:41 How the Big Data Paradox fits in with Katie Coleman's case

54:33 How the Big Data Paradox fits in with other branches of medicine

57:54 How do we rectify subjectivity in The Truth?

01:00:43 How do we address the problems introduced by the Big Data Paradox?

01:04:21 Duality in nature and a Twitter argument re: the Evidence-Based Deep Medicine Iceberg

01:07:03 Why the ideas coming from MD Anderson are coming from MD Anderson

01:09:39 Where you can find Dr Msaouel

Dr Msaouel: https://twitter.com/PavlosMsaouel

Heme Review: https://twitter.com/HemeReview

Production Assistant: Nick Brown

Secret channel:  @BigEmus 

Cancer Patient Speaks With Her Oncologist ► https://youtu.be/Nddft_nc3Yc

A Woman Had A Headache Lasting 3 Days (Katie's case) ► https://www.youtu.be/i9fLEvgZzRE

References:

Stephen Senn. Statistical Issues in Drug Development.

Why representativeness should be avoided. https://academic.oup.com/ije/article/42/4/1012/656034

Commentary: Representativeness is usually not necessary and often should be avoided. https://academic.oup.com/ije/article/42/4/1018/658638

Impervious to Randomness: Confounding and Selection Biases in Randomized Clinical Trials. https://www.tandfonline.com/doi/full/10.1080/07357907.2021.1974030

A Causal Framework for Making Individualized Treatment Decisions in Oncology. https://www.mdpi.com/2072-6694/14/16/3923

Causal Diagram Techniques for Urologic Oncology Research. https://www.sciencedirect.com/science/article/pii/S1558767320301932

Causal inference and the data-fusion problem.

https://www.pnas.org/doi/10.1073/pnas.1510507113

Causal Inference: What If. Miguel A Hernán and James M. Robins. https://www.hsph.harvard.edu/miguel-hernan/wp-content/uploads/sites/1268/2023/04/hernanrobins_WhatIf_31mar23.pdf

There is Individualized Treatment. Why Not Individualized Inference? https://arxiv.org/abs/1510.08539

Unrepresentative big surveys significantly overestimated US vaccine uptake. https://www.nature.com/articles/s41586-021-04198-4

Unrepresentative Big Surveys Significantly Overestimate US Uptake https://arxiv.org/pdf/2106.05818.pdf

Statistical Modeling: The Three Cultures. https://hdsr.mitpress.mit.edu/pub/uo4hjcx6/release/1

How “centaur AI” will radically reshape the future of healthcare. https://bigthink.com/health/how-centaur-ai-will-radically-reshape-the-future-of-healthcare/