Although the nations of the earth rebel against God and His Anointed prior to His return, the response of God is that He laughs at the politicians and rebukes them in His wrath.  This is the reason for the Great Tribulation Period, as the plan has always been to place Jesus Christ on the throne of the earth, ruling from Jerusalem.  God's advice to the kings of the earth is,  "Be wise."  When it comes to the great King Jesus Christ, the nations are not alway wise.  They are foolish.