The start of the 2025 NFL season is here, and for the Tennessee Titans, it is time to kick off the Cam Ward era. The rookie quarterback and the rest of the team face a tall challenge when they travel to Denver for a Week 1 matchup with the Broncos, a team that returns many meaningful contributors and carries as much momentum into this season as any team. Based on the injury report, the challenge could be heightened because it is possible that one of the Titans' key offseason acquisitions might not be available. And in case anyone needed more evidence of what a tall task this opener is, the oddsmakers have made the Titans one of the two biggest underdogs for the NFL's opening weekend.