Shabir Madhi Professor of Vaccinology at the University of the Witwatersrand,Johannesburg, South Africa discusses the effect of the global pandemic on Africa and his work on COVID-19 vaccines. In this episode, Andrew Pollard speaks to Professor Shabir Madhi about his life working in medicine in South Africa and his work on the epidemiology of childhood infectious diseases including HIV. Shabir Madhi is Professor of Vaccinology at the University of the Witwatersrand, Johannesburg, South Africa; and co-founder and co-Director of the African Leadership Initiative for Vaccinology Expertise (ALIVE). His research has focused on the epidemiology, and clinical development of lifesaving vaccines against pneumonia and diarrheal disease. He is leading the first two COVID-19 vaccine studies being undertaken in Africa.