Life-threatening Methicillin-resistant Staphylococcus aureus (MRSA) infections occur most frequently in healthcare settings among patients with weakened immune systems. What do clinicians need to know about preventing MRSA in hospitals, nursing homes, dialysis centers and other healthcare facilities? Dr. John Jernigan, chief of the interventions and evaluation section in the division of healthcare quality promotion at the Centers for Disease Control and Prevention (CDC), delves into the debate over universal screening for MRSA, as well as contact precautions and decolonization regimens, with host Dr. Jennifer Shu.