The Plague of Justinian, one of history’s first recorded pandemics, devastated the Byzantine Empire in the 6th century CE. Caused by the Yersinia pestis bacterium, it swept across Europe, Asia, and North Africa, claiming millions of lives. This catastrophic event weakened the empire’s economy, disrupted trade, and left lasting impacts on medieval society. Believed to have originated from Central Asia, the pandemic underscores the role of trade and climate in disease spread. In today's episode we will be exploring its origins, symptoms, and effects. The Plague of Justinian offers valuable insights into ancient pandemics and their relevance to modern global health challenges