Your body processes acetaminophen via two distinct pathways:

• Phase 2 metabolism (the safe route): 
  ​
  Your liver adds molecules through glucuronidation and sulfation - making it water-soluble so you can pee it out safely.
  ​
• Phase 1 metabolism (the toxic route): 
  ​
  Your body tries to "burn" the acetaminophen through cytochrome P450 oxidation... creating NAPQI - a highly reactive molecule that depletes glutathione (your master antioxidant) and damages mitochondria.

PMID links 

• Cord blood study: Mothers divided into 3 groups by acetaminophen levels at birth. They found a 4x increased risk of Autism with higher exposure. (PMID: 31664451)
  ​
• Animal study (2014): Two doses before day 10 caused permanent brain changes; males more affected. (PMID: 24361869)
  ​
• Neuronal death: Even non-lethal doses kill brain cells in developing animals. (PMID: 21170329)
  ​
• Systematic review (2025): 46 studies - the stronger the study design, the stronger the association. (PMID: 40804730)

 What about the studies "DEBUNKING" it?!”
​
​Those studies are incredibly misleading….

Let’s consider the biggest one, which followed 2.5 million Swedish births. 
​
They compared siblings - one exposed in utero, one not. When they did this, the autism association disappeared. (PMID: 38592388)
​

Intro:

Created by David King

Music by: Andrew Lockington, 

Song: Death Rattle 

Album: Landman soundtrack. 

CFP Point system. 

Because the CFP committee will never allow every group of five champions, or any for that matter into the fold. I propose a point based system for a 12,14, or 16 team playoff. Similar to that of auto racing where drivers are awarded points based on the position they finish.  Those points go toward crowning a champion at the end of the season. 

Here is how it works. 

Due to the archaic, and subjective nature of Strength of schedules, win/losses, and quality of wins… This point system will do away with the subjective criteria we look at now. The teams with the most points will be awarded a place in the playoffs. The points are as follows. 

Regular season Wins against unranked opponents 1pt

Regular season Wins against top 25 opponents 2 pt 

Regular season Wins against top ten opponents  3 pts 

Regular season wins against top five opponents 4 pts 

Additional points for an away game victory is 1pt 

Additional points for a win against a rival 1pt

Conference championship win 8pts 

Regular season loss against a non ranked opponent -3pt

Regular season loss against a top 25 ranked opponent -2pts

Regular season loss against a top ten opponent -1pt 

Regular season loss against a top five opponent - 0pt

Additional Points deducted for a loss at home -1pt

Conference championship loss results in +1 point for attending and no loss in points for losing. 

End of season points, or tie breakers. (points awarded to break ties in the event too many teams qualify for the playoffs). 

• Teams that play out of conference power four teams are rewarded +1 point regardless of outcome. Ie #1 Texas plays Michigan in Ann Arbor, they win. Texas gets +2 for the away win, and +1 for playing a power four team out of conference. Michigan normally would lose -1 but because Texas is ranked and they too played the out of conference power four, they lose no points because they picked up the +1. 
• Teams that start their season with an away game are granted +1 point regardless of outcome. 

BIG TEN

Team                     Points                              Conf. Ranking by points

OREGON  12/0    28pts*                                     1

INDIANA   11/1      15pts 4

PENN STATE 11/1 18pts 3

OHIO STATE 10/2 19pts 2

ILLINOIS 9/3 11pts 5

IOWA 8/4 3pts 7
MICHIGAN 7/5 5pts 6
MINNESOTA 7/5 -4pts 8
USC 6/6 -5pts 9
RUTGERS 7/5 -6pts 12
WASHINGTON 6/6 -5pts 10
NEBRASKA 6/6 -5pts 11
MI STATE 5/7 -10pts 15
UCLA 5/7 -9pts 13
WISCONSIN 5/7 -9pts 14
NORTHWESTERN 4/8 -18pts 17
MARYLAND 4/8 -15pts 16
PURDUE 1/11 -26pts 18

SEC

Team Points Conf. Ranking by points

TEXAS 11/1 16pts 2

GEORGIA 10/2 19pts* 1
TENNESSEE 10/2 15pts 3
MISSOURI 9/3 6pts 6 
OLE MISS 9/3 8pts 5 
ALABAMA 9/3 12pts 4
LSU 8/4 1pts 9
SOUTH CAR. 9/3 7pts 7

TEXAS A&M 7/5 6pts 8
FLORIDA 7/5 1pts 10
ARKANSAS 7/5 -5pts 12
VANDERBILT 6/6 -4pts 11
OKLAHOMA 6/6 -5pts 13
AUBURN 5/7 -14pts 14
KENTUCKY 4/8 -14pts 15
MS. STATE 2/10 -22pts 16

ACC

Team Points Conf. Ranking by points

SMU 11/1 16pts 2

CLEMSON 9/3 21pts* 1

MIAMI 10/2 13pts 3

SYRACUSE 9/3 4pts 6

LOUISVILLE 9/3 6pts 5

DUKE 9/3 9pts 4

BIG12

Team Points Conf. Ranking by points

ARIZONA ST. 10/2 19pts* 1

BYU 10/2 13pts 2

IOWA ST 10/2 10pts 3

COLORADO 9/3 5pts 4

AAC

Team Points Conf. Ranking by points

ARMY 10/2 19pts* 1

NAVY 10/2 10Pts 2

MEMPHIS 10/2 8pts 3

Conference USA

Team Points Conf. Ranking by Points

JAX ST. 6pts*

FBS Independents 

Team Points Conf. Ranking by Points

NOTRE DAME 11/1 17pts

MAC

Team Points Conf. Ranking by Points

OHIO 9/3 13Pts*

Mountain West 

Team Points Conf. ranking by points

BOISE ST 11/1 26pts* 1

UNLV 10/2 14pts 2

Sunbelt

Team Points Conf. Ranking by points

MARSHALL 9/3 14pts* 1

LOUISIANA 10/2 13pts 2

CFP TOP 25 based on points for 2024 compared to Actual Top 25. 

Actual week 15 Top 25 Week 15 Top 25 by points 

1. Oregon* 1. Oregon 28pts*
2. Georgia* 2. Boise St. 26pts*
3. Texas 3. Clemson 21pts*
4. Penn State 4. Georgia 19pts*
5. Notre Dame 5. Arizona St 19pts*
6. Ohio State 6. Army 19pts*
7. Tennessee 7. Ohio State 19pts
8. Indiana 8. Penn State 18pts
9. Boise St* 9. Notre Dame 17pts
10. SMU 10. Texas 16pts
11. Alabama 11. SMU 16pts
12. Arizona St.* 12. Indiana 15pts 11/1
13. Miami 13. Tennessee 15pts 10/2
14. Ole Miss 14. UNLV 14pts 
15. South Carolina 15. Marshall 14pts*
16. Clemson* 16. Miami 13pts
17. BYU 17. BYU 13pts
18. Iowa St. 18. Ohio 13pts*
19. Missouri 19. Louisiana 13pts
20. Illinois 20. Alabama 12pts
21. Syracuse 21. Illinois 11pts
22. Army 22. Iowa St. 10pts
23. Colorado 23. Navy 10pts
24. UNLV 24. Duke 9pts
25. Memphis. 25. Memphis 8pts

CFP top 25 2023 pre conference championship

Georgia  12-0  28Pts / with +1 for Conf. Champ Appearance, and 6 pts for Beating rivals

Michigan 12-0 32pts / with +8 for Conf. Champ Win, and 3pts for beating rivals 

Washington 12-0 31pts / with +8 for Cong Chap win, and 2pts for beating rivals.

Florida State 12-0 30pts / with +8 for Cong Chap win, and 3pts for beating rivals.

Oregon 11-1 17pts / With +1 for Conf. Champ Appearance, and 1pt for beating a rival. 

Ohio State 11-1 20pts / with 1pt for beating a rival

Texas 11-1 29pts / with +8 for Conf. Champ win, and 4pts for beating rivals. 

Alabama 11-1 31pts / With +8 for Conf. Champ, and 5pts for beating rivals.

Missouri 10-2 13pts / +2pts for beating rivals

Penn state 10-2 16pts / +3 for beating rivals

Ole Miss 10-2 18pts / +5 for beating rivals

Oklahoma 10-2 13pts / +1 for beating a rival

LSU 9-3

Louisville 10-2 12pts / +1 for Conf. Champ Appearance, and +1 for beating a rival

Arizona 9-3

Iowa 10-2  18pts / +1 for Conf. Champ Appearance, and +3 for beating a rival

Notre Dame 9-3

Oklahoma St. 9-3

NC state 9-3

Oregon State 8-4

Tennessee 8-4

Tulane 11-1 14pts / +1 point for attending Conf. Champ.

Clemson 8-4

Liberty 12-0 26pts / with +8 for Cong Chap win, and 1pt for beating rival.

Kansas state 8-4

12 Teams ranking:

1. Michigan 32pts 12/0*
2. Washington 31pts 12/0*
3. Alabama 31pts 11/1*
4. Florida state 30pts 12/0*
5. Texas 29pts 11/1*
6. Georgia 28pts 12/0
7. Liberty 26pts 12/0*
8. Ohio State 20pts 11/1
9. Ole Miss 18pts 10/2
10. Iowa 18pts 10/2
11. Oregon 17pts 11/1
12. Penn State 16pts. 10/2

First Three out

1. Tulane 14pts 11/1 
2. Missouri 13pts 10/2 
3. Oklahoma 13pts 10/2

* Denotes conference champion. 

Key notes: 

Pros: 

• love the mic'd up players, although we are getting interactions more from who we would expect than others. Tiger was rigid in the beginning but loosened up after his team was all but put to bed for sure. 
• The extreme golf courses on the sim.  I am glad this isn't the same old stuff in real life.  I like the idea of fantasy style courses that are hard to play. 
• The tech is awesome, and the greens are a show stopper. 
• Fans and atmosphere looks very cool 

Cons:

• The scoring, Match play doesn't work for this. At least so far it hasn't.  Both games are blowouts.  Should be a stable ford setup or something different. 
• It's not as engaging as it could be. Maybe because the drama has been low. But I think a single announcer and no in field announcers hurts. 
• Courses need to be harder, need to challenge the players more.