Increasingly, depression is viewed a systems-level disorder. For patients who are refractory to the all traditional therapies, surgery on the brain may be answer. What are the benefits, and how is psychosurgery different than it was 50 years ago? Dr. Leslie Lundt is joined by Dr. Aviva Abosch, director of the Epilepsy and Functional Neurosurgery Program, and assistant professor in the department of neurosurgery, at the University of Minnesota Medical School in Minneapolis.