In this episode of KDIGO Conversations in Nephrology, Dr. Carla Nester, Professor of Internal Medicine and Pediatrics at the University of Iowa's Stead Family Children's Hospital, is joined by Dr. Matthew Pickering, Professor of Rheumatology at Imperial College London.

Together, Drs. Nester and Pickering discuss the role of the complement system in complement-driven versus complement-associated kidney diseases and the clinical implications of this distinction. They explore the pros and cons of targeting different pathways and components of the complement system, such as C3, C5, and C5a. Dr. Pickering shares insights into the importance of understanding the pathophysiology for targeted treatments and how the understanding of complement activation can translate into advancements in complement therapies. The discussion also covers the use of circulating biomarkers to help clinicians potentially better diagnose, prognosticate, and evaluate treatment response.

This episode is a must-listen for anyone interested in the latest developments in nephrology and the future of precision medicine in treating kidney diseases; it’s supported by Apellis and Sobi.