This episode explores the evidence on vitamin D and its role in the pathophysiology and clinical management of polycystic ovary syndrome (PCOS), with a focus on metabolic and reproductive outcomes. We break down proposed biological mechanisms, key findings from recent trials and reviews, and practical considerations for screening and supplementation in clinical practice. Designed for dietitians and women’s health professionals, this episode supports evidence-informed decision making when caring for individuals with PCOS.

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References:

1. Vitamin D and Polycystic Ovary Syndrome (PCOS): A Narrative Review (2025): [Akhter, D.S., Hannan, D.K., Chowdury, D.S., & Nasrin, D.S. (2025). Vitamin D and Polycystic Ovary Syndrome (PCOS): A Narrative Review. Scholars Journal of Applied Medical Sciences.]
2. Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial (2024): [Wen, X., Wang, L., Li, F., & Yu, X. (2024). Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: A randomized controlled trial. Journal of Ovarian Research, 17(1). https://doi.org/10.1186/s13048-024-01473-6
3. Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial (2024)(2025): [Tóth, B. E., Takács, I., Valkusz, Z., Jakab, A., Fülöp, Z., Kádár, K., Putz, Z., Kósa, J. P., & Lakatos, P. (2025). Effects of vitamin D3 treatment on polycystic ovary symptoms: A prospective double-blind two-phase randomized controlled clinical trial. Nutrients, 17(7), 1246. https://doi.org/10.3390/nu17071246]
4. The impact of vitamin D supplementation on glycemic control and lipid metabolism in polycystic ovary syndrome: a systematic review of randomized control trials: [Yu, M., Chen, S., Liu, X., Dong, H., & Wang, D.-C. (2025). The impact of vitamin D supplementation on glycemic control and lipid metabolism in polycystic ovary syndrome: A systematic review of randomized controlled trials. BMC Endocrine Disorders, 25(1). https://doi.org/10.1186/s12902-025-01920-5]
5. Effect of vitamin D supplementation on lipid profile, and hormonal function in polycystic ovary syndrome: An umbrella systematic review and meta-analysis (2024): Tony Yin et.al.,: [Yin, T., Lin, W., Ming, K., Lv, H., Wang, Y., Yuanchao, L., Zhen, H., Yuan, J., & Asadi, H. (2024). Effect of vitamin D supplementation on lipid profile, and hormonal functions in polycystic ovary syndrome: An umbrella systematic review and meta-analysis. Prostaglandins & Other Lipid Mediators, 175, 106913. https://doi.org/10.1016/j.prostaglandins.2024.106913]