This video by Creative Biolabs, tailored for biological researchers, delivers a conversational overview of the science behind humanized mouse models—covering their definition, classification, construction strategies, core applications (drug screening, drug metabolism and toxicity assessment, personalized therapy), success cases in tumor immunotherapy and infectious disease/vaccine development, technical limitations, comparisons with alternative models, and the lab’s related services—to help viewers understand the models’ value in bridging preclinical research and clinical drug development.