Why do some people with adrenal insufficiency still feel flat, unmotivated, or “hollow” even when their labs look stable and they are taking their replacement steroids correctly?

In this episode, Chloe and Alex explore a My Adrenal Life topic that many patients recognize but rarely hear explained clearly: the role of DHEA and adrenal androgens in adrenal insufficiency.

Standard treatment for adrenal insufficiency usually focuses on replacing the hormones most essential for survival: cortisol and, in Primary Adrenal Insufficiency (Addison’s disease), aldosterone. But the adrenal glands also produce another important group of hormones from the zona reticularis: adrenal androgens, especially DHEA and DHEA-S.

These hormones are usually not routinely replaced.

The episode explains why that gap may matter.

DHEA is often thought of as simply a weak androgen or a hormone precursor, but it also acts as a neurosteroid, meaning it influences brain function directly. It crosses the blood-brain barrier and interacts with systems involved in mood, motivation, resilience, and reward signaling.

For some people with adrenal insufficiency, especially women, the loss of DHEA may contribute to symptoms such as:

• low libido
• reduced motivation or “spark”
• emotional flatness
• muscle weakness
• slower physical recovery
• feeling “stable” but not truly well

This may be especially noticeable in Primary Adrenal Insufficiency, where the adrenal cortex is damaged and DHEA production can drop very low. But it can also occur in Secondary, Tertiary, and steroid-induced adrenal insufficiency, because ACTH signaling also helps stimulate DHEA production.

Chloe and Alex also explain why women may be affected more strongly. In men, the testes provide a major source of androgens, so the loss of adrenal DHEA may be less dramatic. In women, the adrenal glands contribute a much larger share of androgen production, so the drop can feel much more significant.

The episode also explores why DHEA replacement is not yet standard for everyone. Research has shown mixed results. Some studies found improvements in mood, libido, and quality of life, particularly in women with adrenal insufficiency. Other studies showed less consistent benefit. DHEA can also cause side effects such as acne, oily skin, or increased facial hair if dosing is too high.

Because of that, current endocrine guidelines do not recommend DHEA universally. However, it may be considered in carefully selected patients—especially women with Primary Adrenal Insufficiency who continue to have low libido or reduced well-being despite otherwise optimized treatment.

This episode emphasizes an important point: “normal” lab ranges do not always reflect a person’s individual baseline or fully explain how they feel. A patient can be medically stable and still feel like something important is missing.

The conversation encourages patients to optimize their basic replacement first, then speak with a qualified endocrinologist if symptoms like flat mood, low drive, or persistent reduced well-being continue.

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