In this lively and deeply informative episode of The Spot Check, host Jamie Restivo, MPAS, PA-C, sits down with Benjamin Lockshin, MD, dermatologist and Director of the Clinical Trials Center at U.S. Dermatology Partners, to unpack one of the most promising frontiers in atopic dermatitis (AD): targeting the OX40–OX40 ligand pathway. 

Together, they review the AD treatment landscape and current gaps in therapies. Lockshin outlines the promise of OX40 inhibition as a potential step toward true disease modification, with less frequent dosing and durable remission that could reshape long-term disease management. 

Restivo and Lockshin walk listeners through the immunologic mechanisms at play, breaking down how OX40 and its ligand function as upstream co-stimulatory molecules driving inflammation, barrier dysfunction, and itch. They compare emerging agents rocatinlimab and amlitelimab, explaining how each targets a different side of the OX40 pathway, and discuss early data showing high EASI-90 to EASI-100 responses and sustained clearance even after treatment withdrawal. 

Their conversation delves into what makes these agents distinct from JAK inhibitors and biologics, emphasizing that OX40 inhibition appears to rebalance rather than deplete T cells, with minimal immunosuppression and a favorable safety profile so far. Lockshin shares practical considerations around patient selection, dosing convenience, and future applications beyond AD—including prurigo nodularis, alopecia areata, and potential oncologic uses. 

The discussion closes on a forward-looking note: OX40 may be dermatology’s first real leap toward immune reprogramming. As Lockshin puts it, “good things are worth the wait,” and OX40 inhibition could mark the next chapter in changing the course–not just the symptoms—of atopic dermatitis. 

The Spot Check, host Jamie Restivo, MPAS, PA-C, welcomes Scott Dinehart, MD, board-certified dermatologist, Mohs surgeon, and founder of Arkansas Dermatology, for a frank and myth-busting discussion on hedgehog pathway inhibitors (HHIs) and their role in treating locally advanced basal cell carcinoma (BCC). 

Dr Dinehart, one of the first fellowship-trained Mohs surgeons in Arkansas, shares his firsthand experience with vismodegib and sonidegib, emphasizing that PAs and NPs are ideal prescribers for these agents and should feel confident managing this patient population. He addresses common misconceptions about efficacy and tolerability head-on, noting that “These drugs work—and they work

Together, they explore clinical indications for sonidegib and discuss expanding the mindset beyond large, neglected tumors. Dinehart

Supplemental Clinical Resources:

To support adoption of HHIs in everyday practice, Dr Dinehart has provided two references: 

Sonidegib Quick Reference Sheet: summarizes key prescribing information, laboratory guidance, drug-interaction tables, and L-carnitine dosing details for muscle-cramp prevention. 

HHI Dosing Calendar: a visual schedule illustrating his modified twice-weekly regimen to aid patient counseling and adherence tracking. 

For clinicians who have additional questions or would like to discuss treatment approaches, Dr Dinehart welcomes inquiries at [email protected]. 

In this extended cut of The Spot Check, new host Jamie Restivo, MPAS, PA-C, welcomes Andrew Mastro, MS, PA-C, for a deep and dynamic conversation centered on dupilumab and its broadening role in dermatologic care. 

Together, they unpack the science behind type 2 inflammation and the mechanisms that make dupilumab effective across eight FDA-approved indications, including atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, prurigo nodularis, bullous pemphigoid, and chronic spontaneous urticaria (CSU). Mastro offers a practical breakdown of type 2 cytokine activity and discusses how targeting these pathways drives disease control across skin, lung, and GI conditions. 

The pair discuss first-line use of dupilumab in AD, emphasizing its safety profile, FDA approval down to 6 month of age, and ability to treat multiple comorbidities. They also explore new territory with bullous pemphigoid, reviewing data from the ADEPT trial, the challenges of oral corticosteroids in elderly patients, and how dupilumab might offer a safer, targeted alternative. 

Mastro shares thoughtful insights on treating prurigo nodularis, advocating for aggressive, empathetic care and cautioning clinicians not to delay treatment as a biopsy is not necessary to make this diagnosis. He stresses the importance of documenting thoroughly and recognizing PN even in the absence of nodules. 

The episode concludes with a discussion on chronic spontaneous urticaria (CSU), including diagnostic criteria, evolving treatment approaches, and patient expectations. They push back on outdated, exhaustive lab workups and advocate for focused history-taking and up-dosing antihistamines before initiating biologic therapy. 

With clinical pearls throughout—including how to frame conversations with patients about long-term therapy, how to document for coverage, and when to lead with systemic options—this extensive conversation offers a masterclass in therapeutic decision-making, delivered with humor, heart, and high-level clinical insight. 

In this episode of The Spot Check, host Lauren Miller, PA-C, sits down with Rob Casquejo, PA-C, of Better Skin Dermatology in Scottsdale, Arizona, for a lively and insightful conversation on the biggest dermatology trends of 2025. 

From new systemic therapies like OX40 ligand and oral IL-23 inhibitors to the expanding role of GLP-1 medications in inflammatory skin diseases, they break down what’s next in derm. The pair also touch on tech innovations like virtual reality in the treatment room, the rise and fall of teledermatology, and how social media is shaping (and sometimes skewing) the skincare conversation. 

Plus, don’t miss their fun game segments, where they dish on trends they’d “treat, trial, or trash,” and reveal their derm word associations in “Spot On.” 

Whether you’re tuning in for clinical insights, career inspiration, or perspectives on emerging trends, this episode has what you need to stay current and continue growing in your practice. 

In this episode of The Spot Check, Lauren Miller, PA-C, and guest TJ Chao, PA-C, discuss how dermatology PAs and NPs can confidently explain JAK inhibitors to patients. They cover the basics of JAK inhibitors, the JAK-STAT pathway, and why understanding these mechanisms is crucial for effective patient counseling. They also address FDA boxed warnings, explaining their origins and how to contextualize safety concerns for dermatologic treatments.

Tune in to gain insights into the importance of educating patients about both the benefits and risks of JAK inhibitors and hear success stories and practical tips for providers to build confidence in prescribing these therapies.

Welcome to Episode 2 of The Spot Check, a new series from Dermsquared that highlights key special events, upcoming conferences, professional opportunities, and more! In this episode, James Q. Del Rosso, DO, speaks with Lauren Miller, PA-C, of Southern Skies Dermatology in Oxford, AL, to spotlight the upcoming 2024 Fall Clinical Dermatology Conference for PAs and NPs (FCPANP) taking place May 31 – June 2 in Scottsdale, Arizona!

FCPANP offers PAs and NPs an opportunity to enhance their clinical skills through a thoughtfully crafted learning experience. The agenda features succinct lectures covering a diverse array of topics, brimming with clinically relevant insights and practical guidance on professional development. The program also features interactive panel sessions, Q&A segments, a live patient demonstration, and ample networking opportunities to equip participants with invaluable skills to elevate patient care.

Tune into the episode for an in-depth preview of what awaits at FCPANP. Don't miss out on this exceptional opportunity to broaden your expertise, connect with fellow professionals, and make a powerful impact on patient lives. For virtual attendance, register today using promo code SPOTCHECK24 to receive free access to FCPANP.

Welcome to Episode 1 of The Spot Check, a new series from Dermsquared that highlights key special events, upcoming conferences, professional opportunities, and more! In this episode, James Q. Del Rosso, DO, leads a discussion with Lauren Miller, PA-C, of Southern Skies Dermatology in Oxford, AL, to spotlight the upcoming 2024 Inflammatory Disease Summit (IDS) for PAs and NPs in New York City on May 18.

IDS is an exclusive learning opportunity for PAs and NPs seeking to expand their knowledge of inflammatory diseases in dermatology and the ever-expanding treatment landscape. The dynamic agenda includes didactic lectures, an impactful patient interview highlighting the psychosocial impact of inflammatory diseases, and interactive breakout sessions offering practical demonstrations and hands-on experiences, empowering attendees with valuable skills to elevate patient care.

Tune in to the episode for a full rundown of what to expect at IDS, and don't miss out on this unparalleled opportunity to expand your knowledge, network with peers, and make a tangible difference in the lives of patients with inflammatory diseases. Register today using the promo code IDS24RIGEL to secure your seat at IDS 2024!