We’ve seen how a thumbtack to the foot can trigger an electrical storm in your nerves — but how does that signal jump from one neuron to the next? Welcome to the synapse, the tiny but mighty junction where information changes hands.

In this episode, we trace the story from the late 1800s, when scientists first realized neurons don’t just touch — they communicate. Early researchers like Charles Sherrington gave this mysterious meeting point a name, while others debated whether neurons talked through electricity or chemistry.

We’ll follow the experiments that settled the score — from Otto Loewi’s famous frog heart experiment that revealed chemical messengers, to Bernard Katz’s work showing how nerve impulses trigger neurotransmitter release, and John Eccles’ discovery that most brain synapses rely on chemical signaling.

Today, we know that synaptic transmission is at the heart of everything the nervous system does — from reflexes to memory, emotions to mental illness.

Join us as we unpack how these tiny connections create the grand symphony of the brain: how neurotransmitters are made, stored, and released, and how every signal you think, feel, or remember begins at the space between two neurons.