In this episode of the Active Ingredients podcast, host Thomas Dove interviews Jesse Sibarium, a seasoned life sciences executive with experience spanning supply chain and commercial leadership across multiple continents.

Jesse's unconventional path from Manhattan to Moldova, Romania, the Netherlands, and Switzerland demonstrates how cultural immersion and calculated risk-taking can create what he calls "leadership luck." His journey through organisations, including Amgen and PTC Therapeutics, offers insights into building credibility through lived experience rather than traditional career progression.

The conversation explores global adaptability, decision-making under pressure, and the evolving landscape of pharmaceutical leadership in an increasingly interconnected world.

Key Takeaways

• Learn how curiosity and inner drive serve as foundational leadership qualities, particularly when entering unfamiliar territories or industries where traditional experience may not apply.
• Discover the critical importance of selecting diverse teams with complementary skills, personalities, and nationalities who will challenge you while supporting your vision through difficult periods.
• Understand that resilience and grit become essential when carefully crafted plans inevitably face unexpected challenges, requiring leaders to adapt quickly without losing momentum.
• Explore how cultural immersion creates competitive advantages, with Jesse's language learning experiences in Moldova and the Netherlands opening doors that traditional qualifications could not.
• Take away strategies for creating "leadership luck" by positioning yourself in uncomfortable situations where unique opportunities may emerge for those willing to take calculated risks.
• Gain insights into transitioning between large pharma and smaller biotech environments, understanding when each setting serves different career development purposes.
• Apply frameworks for building international teams that can operate seamlessly across multiple jurisdictions and cultural contexts in today's globalised pharmaceutical landscape.
• Uncover how soft skills increasingly function as hard skills in leadership roles, particularly in relationship-building and cross-cultural communication within life sciences organisations.

Snippets

• "Some people see things as they are and ask why. Some people dream things that never were and ask, why not?"
• "I thought, there is no way I can quit, because if I can make it here, I can make it anywhere."
• "Don't underestimate those soft skills, because the soft skills are really the hard skills."

Timestamps & Topics

• 00:16:27 -- Introduction: Jesse's journey from Manhattan to international pharmaceutical leadership

• 00:17:56 -- Three Active Ingredients: Curiosity, team selection, and resilience as leadership foundations
• 00:23:05 -- Early Formation: High school performing arts lessons that shaped professional mindset
• 00:28:12 -- Global Awakening: Meeting international people and developing an appetite for a European career
• 00:30:01 -- The Moldova Gamble: Taking risks through Peace Corps to create an unconventional pathway to Europe
• 00:42:59 -- Leadership Luck: Creating opportunities through cultural immersion and language learning
• 01:02:25 -- Future of Leadership: Diverse backgrounds, international experience, and evolving pharmaceutical landscape

Resources

• Follow Jesse Sibarium on LinkedIn: https://www.linkedin.com/in/sibarium/

• Follow Thomas Dove on LinkedIn: https://www.linkedin.com/in/lifesciencesexecutivesearch/

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