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The "Winter Blues" Paradox
For forty years, we’ve been telling the same story about seasonal depression: get a light box, take vitamin D, wait for spring.
But what if the entire framework is wrong?
In this episode, I’m connecting two stories that have never been told together—and the implications for mental health care are massive.
What This Episode Covers
The Buried Controversy
A 2006 CDC study of 34,000+ Americans found zero evidence for seasonal affective disorder as a distinct condition. No seasonal patterns in depression. No correlation with latitude or sunlight hours. Even among people already experiencing depression, there was no winter spike.
This research has been largely ignored. Meanwhile, we keep prescribing light boxes and calling it evidence-based care.
The Population We’ve Been Ignoring
If seasonal mood changes ARE linked to vitamin D deficiency (which affects serotonin and dopamine production), we’ve been studying the wrong people for decades.
Here’s why: Melanin blocks UV-B radiation—the wavelength needed for vitamin D synthesis. People with darker skin require significantly more sun exposure to produce the same amount of vitamin D. African Americans have a 15 to 20-fold higher prevalence of severe vitamin D deficiency compared to European Americans. About 70% are deficient.
Yet mainstream coverage of seasonal depression focuses almost exclusively on populations with lighter skin. Black community health outlets mention the vitamin D gap, but still frame it as “managing a well-established condition better.”
Nobody is asking: What if the entire research paradigm has been backwards from the start?
The Precision Medicine Problem
When someone reports feeling low in January, our current approach is generic: try light therapy, consider antidepressants, increase vitamin D intake.
But what if we asked instead:
* Is this part of a multi-year pattern for this individual?
* Does this person’s skin pigmentation affect their vitamin D synthesis at their current latitude?
* Are there modifiable risk factors we should flag before symptoms become severe?
That’s the difference between reactive mental health care and prevention-first precision medicine. And it’s what we’re building with Kay AI at KindPath Health—tools that account for individual risk factors, not one-size-fits-all assumptions.
Three Things Mainstream Media Won’t Tell You
* The science isn’t settled. Researchers legitimately debate whether SAD exists as a distinct condition, but this controversy rarely makes it into public health messaging.
* Skin pigmentation matters. A 2021 genome-wide study identified specific genetic variants (SLC24A5, SLC45A2, OCA2) linked to both darker skin and severe vitamin D deficiency—but this connection is absent from most SAD discussions.
* “Colorblind” medicine perpetuates disparities. When we ignore biological factors like melanin’s effect on vitamin D synthesis, we’re not being equitable—we’re being negligent.
Key Quotes from the Episode
“We should not shy from this new study looking at the genetics of skin color and its effects on vitamin D deficiency because being ‘colorblind’ is what has led to the widespread health disparities that we as a society are now trying to address.”—Dr. Rick Kittles, Director of Health Equities, Beckman Research Institute
“Being ‘colorblind’ in medicine doesn’t make us equitable. It makes us ignorant. And in mental health care, ignorance isn’t just an intellectual failure—it’s a clinical one.”
What You Can Do
If you struggle in winter: Your experience is valid, but “seasonal affective disorder” might not capture what’s actually happening. Consider whether the generic advice you’ve received addresses your specific risk factors.
If you have darker skin and live at higher latitudes: Ask your doctor to check your vitamin D levels year-round—not just in winter. This affects mood, cardiovascular health, immune function, and more. Supplementation is cheap and evidence-based.
If you’re building health tech: Are you baking equity into your algorithms from the start, or treating it as a “diversity add-on”? Risk assessment tools that don’t account for population-specific factors aren’t just incomplete—they’re actively harmful.
Why This Matters for Mental Health Innovation
Recent research tracked 428 people using mobile health data and found four distinct subgroups with completely different seasonal depression patterns. One group had stable depression year-round. Others peaked at different seasons.
Seasonal depression isn’t one thing. It’s not one mechanism. And lumping everyone under the same diagnosis means we’re missing opportunities for precision intervention.
At KindPath Health, we’re building Kay AI to track individual patterns over time—not generic seasonal trends. When someone reports low mood in January for the third year running, the system should flag modifiable risk factors like vitamin D screening. That’s prevention-first mental health.
But we can only build these tools well if we’re honest about who’s been left out of the research.
Sources Referenced
* Scientific American (2024): Analysis of CDC study questioning SAD’s existence
* Stewart et al. (2014): “Possible contributions of skin pigmentation and vitamin D in a polyfactorial model of seasonal affective disorder”
* Kittles et al. (2021): First genome-wide association study on skin pigmentation and vitamin D deficiency in African Americans
* Ames, Grant & Willett (2021): “Does the high prevalence of vitamin D deficiency in African Americans contribute to health disparities?”
* Zhang et al. (2025): Mobile health study identifying four distinct seasonal depression subgroups
Full citations available in the episode transcript.
Got thoughts on this? I’d love to hear from you—especially if this changes how you think about seasonal mood changes or if you have personal experience with the vitamin D/melanin connection. Reply to this email or leave a comment below.
Share this episode if you know someone who needs to hear this story. Especially clinicians, researchers, and anyone building mental health tools.
And maybe—just maybe—check your vitamin D levels while you’re at it.
—Melody
Unmaked is a mental health newsletter covering the intersections of digital health, healthcare policy, and healthtech/AI—spotlighting the quiet but powerful changes shaping the future of care.
Want to support this work? Share this episode, leave a review, or subscribe for free!
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit melodymejeh.substack.com
View all episodes
By Melody MejehFor forty years, we’ve been telling the same story about seasonal depression: get a light box, take vitamin D, wait for spring.
But what if the entire framework is wrong?
In this episode, I’m connecting two stories that have never been told together—and the implications for mental health care are massive.
What This Episode Covers
The Buried Controversy
A 2006 CDC study of 34,000+ Americans found zero evidence for seasonal affective disorder as a distinct condition. No seasonal patterns in depression. No correlation with latitude or sunlight hours. Even among people already experiencing depression, there was no winter spike.
This research has been largely ignored. Meanwhile, we keep prescribing light boxes and calling it evidence-based care.
The Population We’ve Been Ignoring
If seasonal mood changes ARE linked to vitamin D deficiency (which affects serotonin and dopamine production), we’ve been studying the wrong people for decades.
Here’s why: Melanin blocks UV-B radiation—the wavelength needed for vitamin D synthesis. People with darker skin require significantly more sun exposure to produce the same amount of vitamin D. African Americans have a 15 to 20-fold higher prevalence of severe vitamin D deficiency compared to European Americans. About 70% are deficient.
Yet mainstream coverage of seasonal depression focuses almost exclusively on populations with lighter skin. Black community health outlets mention the vitamin D gap, but still frame it as “managing a well-established condition better.”
Nobody is asking: What if the entire research paradigm has been backwards from the start?
The Precision Medicine Problem
When someone reports feeling low in January, our current approach is generic: try light therapy, consider antidepressants, increase vitamin D intake.
But what if we asked instead:
* Is this part of a multi-year pattern for this individual?
* Does this person’s skin pigmentation affect their vitamin D synthesis at their current latitude?
* Are there modifiable risk factors we should flag before symptoms become severe?
That’s the difference between reactive mental health care and prevention-first precision medicine. And it’s what we’re building with Kay AI at KindPath Health—tools that account for individual risk factors, not one-size-fits-all assumptions.
Three Things Mainstream Media Won’t Tell You
* The science isn’t settled. Researchers legitimately debate whether SAD exists as a distinct condition, but this controversy rarely makes it into public health messaging.
* Skin pigmentation matters. A 2021 genome-wide study identified specific genetic variants (SLC24A5, SLC45A2, OCA2) linked to both darker skin and severe vitamin D deficiency—but this connection is absent from most SAD discussions.
* “Colorblind” medicine perpetuates disparities. When we ignore biological factors like melanin’s effect on vitamin D synthesis, we’re not being equitable—we’re being negligent.
Key Quotes from the Episode
“We should not shy from this new study looking at the genetics of skin color and its effects on vitamin D deficiency because being ‘colorblind’ is what has led to the widespread health disparities that we as a society are now trying to address.”—Dr. Rick Kittles, Director of Health Equities, Beckman Research Institute
“Being ‘colorblind’ in medicine doesn’t make us equitable. It makes us ignorant. And in mental health care, ignorance isn’t just an intellectual failure—it’s a clinical one.”
What You Can Do
If you struggle in winter: Your experience is valid, but “seasonal affective disorder” might not capture what’s actually happening. Consider whether the generic advice you’ve received addresses your specific risk factors.
If you have darker skin and live at higher latitudes: Ask your doctor to check your vitamin D levels year-round—not just in winter. This affects mood, cardiovascular health, immune function, and more. Supplementation is cheap and evidence-based.
If you’re building health tech: Are you baking equity into your algorithms from the start, or treating it as a “diversity add-on”? Risk assessment tools that don’t account for population-specific factors aren’t just incomplete—they’re actively harmful.
Why This Matters for Mental Health Innovation
Recent research tracked 428 people using mobile health data and found four distinct subgroups with completely different seasonal depression patterns. One group had stable depression year-round. Others peaked at different seasons.
Seasonal depression isn’t one thing. It’s not one mechanism. And lumping everyone under the same diagnosis means we’re missing opportunities for precision intervention.
At KindPath Health, we’re building Kay AI to track individual patterns over time—not generic seasonal trends. When someone reports low mood in January for the third year running, the system should flag modifiable risk factors like vitamin D screening. That’s prevention-first mental health.
But we can only build these tools well if we’re honest about who’s been left out of the research.
Sources Referenced
* Scientific American (2024): Analysis of CDC study questioning SAD’s existence
* Stewart et al. (2014): “Possible contributions of skin pigmentation and vitamin D in a polyfactorial model of seasonal affective disorder”
* Kittles et al. (2021): First genome-wide association study on skin pigmentation and vitamin D deficiency in African Americans
* Ames, Grant & Willett (2021): “Does the high prevalence of vitamin D deficiency in African Americans contribute to health disparities?”
* Zhang et al. (2025): Mobile health study identifying four distinct seasonal depression subgroups
Full citations available in the episode transcript.
Got thoughts on this? I’d love to hear from you—especially if this changes how you think about seasonal mood changes or if you have personal experience with the vitamin D/melanin connection. Reply to this email or leave a comment below.
Share this episode if you know someone who needs to hear this story. Especially clinicians, researchers, and anyone building mental health tools.
And maybe—just maybe—check your vitamin D levels while you’re at it.
—Melody
Unmaked is a mental health newsletter covering the intersections of digital health, healthcare policy, and healthtech/AI—spotlighting the quiet but powerful changes shaping the future of care.
Want to support this work? Share this episode, leave a review, or subscribe for free!
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit melodymejeh.substack.com