This Chapter from The Yellow Emperor’s Classic of Internal Medicine discusses ancient Chinese medicine. Huangdi, the Yellow Emperor, questions Qibo, a renowned physician, about the preparation and use of herbal remedies derived from the five grains. Their conversation explores the efficacy of these remedies in different eras, emphasizing the importance of harmony between heaven and earth in their preparation and the crucial role of spiritual well-being in healing. The discussion also highlights the importance of early intervention and balancing the body's energies for successful treatment. Finally, a specific severe illness and its treatment is described, emphasizing the need for a holistic approach.