The statement that "these drugs are weapons of mass destruction" is a perspective primarily used by some U.S. politicians and law enforcement officials, particularly regarding fentanyl, due to its extreme potency and the high number of overdose deaths it causes. Fentanyl, a synthetic opioid 50 to 100 times more potent than heroin, is the leading cause of death for American adults aged 18 to 45. The vast scale of overdose deaths has led some officials to use the "weapon of mass destruction" (WMD) rhetoric to emphasize the severity of the crisis and the need for a more aggressive, all-of-government response.

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