Welcome to This Week in Rheumatology. This week we're covering 9 notable papers spanning new therapeutic paradigms like CAR-T cell therapy [7], optimizing treatment in challenging populations like lupus nephritis [3] and elderly vasculitis [4], and innovations in diagnostics for conditions from myositis-ILD [8] to hand osteoarthritis [5]. We'll also touch on the growing global burden of mental hea…

This week's papers:

1. Genomic instability drives POSTNmyofibroblasts via STING-WNT axis to promote immunosuppression and PARPi resistance in ovarian cancer. — Science translational medicine 2026
2. Decoding variants of uncertain significance in systemic autoinflammatory diseases. — Nature reviews. Rheumatology 2026
3. Early belimumab accelerates renal response and reduces glucocorticoid exposure in lupus nephritis: a multicenter propensity-matched study. — Rheumatology (Oxford, England) 2026
4. Incorporating frailty and disease severity into treatment decisions for older patients with ANCA-associated vasculitis. — Rheumatology (Oxford, England) 2026
5. Radiomics Grading of Hand Osteoarthritis Severity Using Standard Radiographs: Results from the DIGICOD Cohort. — Osteoarthritis and cartilage 2026
6. Resetting autoimmune disease with CAR cell therapies. — Nature medicine 2026
7. Serum KL-6 and lung ultrasound B-lines: a combined non-invasive model for screening and predicting interstitial lung disease in idiopathic inflammatory myopathy. — RMD open 2026
8. Updated trends in the global prevalence and burden of mental disorders, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. — Lancet (London, England) 2026

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